Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | HPGD | P15428 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.59 |
| ▸ | RELA | Q04206 | 3/20 | 0.59 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22822617 | 0.90 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL16291782 | 0.81 | MAPT (0.53) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL16291783 | 0.81 | MAPT (0.53) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL20767461 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL20767462 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL22822640 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL24120015 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL22822622 | 0.76 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL22822870 | 0.76 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL22822636 | 0.75 | ALDH1A1 (0.76) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10633369-B2 | Method of inhibiting DYRK1B | 4 SC AG (DE) | 2020-04-28 | — | — | US | disclosed |
| US-20180201606-A1 | METHOD OF INHIBITING DYRK1B | 4 SC AG (DE) | 2018-07-19 | — | — | US | disclosed |
| US-9951050-B2 | Method of inhibiting DYRK1B | 4 SC AG (DE) | 2018-04-24 | — | — | US | disclosed |
| US-20140371251-A1 | METHOD OF INHIBITING DYRK1B | 4SC DISCOVERY GMBH (DE) | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633369-B2 | Method of inhibiting DYRK1B | SMO, GLI1, GRK2 | SMN1; SMN2 4360/4885ALDH1A1 3401/4885MAPT 4239/4885 |
| US-20180201606-A1 | METHOD OF INHIBITING DYRK1B | SMO, GLI1, GRK2 | SMN1; SMN2 4360/4885ALDH1A1 3401/4885MAPT 4239/4885 |
| US-20140371251-A1 | METHOD OF INHIBITING DYRK1B | SMO, GLI1, GRK2 | SMN1; SMN2 4360/4885ALDH1A1 3401/4885MAPT 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.