Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.65 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 11/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | HPGD | P15428 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | HTT | P42858 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.63 |
| ▸ | GAA | P10253 | 5/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.63 |
| ▸ | RELA | Q04206 | 4/20 | 0.63 |
| ▸ | GLA | P06280 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20767461 | 1.00 | SMN1; SMN2 (0.65) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL24120015 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL16291785 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL22822636 | 0.81 | ALDH1A1 (0.76) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL22822622 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL22822870 | 0.78 | SMN1; SMN2 (0.73) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL22822804 | 0.77 | SMN1; SMN2 (0.81) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL28708639 | 0.77 | KCNH2 (0.59) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL29467867 | 0.77 | KCNH2 (0.59) | SMN1; SMN2TP53RAB9AALDH1A1KDM4E | |
| SCHEMBL9543194 | 0.74 | HRH1 (0.56) | TP53RAB9AKCNH2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12371406-B2 | Dual acting FKBP12 and FKBP52 inhibitors | PLEX PHARMACEUTICALS, INC. (US) | 2025-07-29 | — | — | US | disclosed |
| US-12065407-B2 | Dual acting FKBP12 and FKBP52 inhibitors | PLEX PHARMACEUTICALS, INC. (US) | 2024-08-20 | — | — | US | disclosed |
| US-20210395203-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. | 2021-12-23 | — | — | US | disclosed |
| US-20200399219-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. | 2020-12-24 | — | — | US | disclosed |
| EP-3672934-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | Plex Pharmaceuticals, Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019040463-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. (US) | 2019-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399219-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | FKBP2, FKBP1B, FKBP1A | SMN1; SMN2 379/4885TP53 2291/4885RAB9A 1223/4885 |
| US-20210395203-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | FKBP2, FKBP1B, FKBP1A | SMN1; SMN2 379/4885TP53 2291/4885RAB9A 1223/4885 |
| US-12065407-B2 | Dual acting FKBP12 and FKBP52 inhibitors | FKBP2, FKBP1B, FKBP1A | SMN1; SMN2 379/4885TP53 2291/4885RAB9A 1223/4885 |
| US-12371406-B2 | Dual acting FKBP12 and FKBP52 inhibitors | FKBP2, FKBP1B, FKBP1A | SMN1; SMN2 379/4885TP53 2291/4885RAB9A 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.