Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.73 |
| ▸ | MAPT | P10636 | 8/20 | 0.73 |
| ▸ | TP53 | P04637 | 5/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.68 |
| ▸ | RAB9A | P51151 | 8/20 | 0.68 |
| ▸ | NPC1 | O15118 | 7/20 | 0.68 |
| ▸ | GAA | P10253 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.68 |
| ▸ | GLA | P06280 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13166604 | 0.90 | SMN1; SMN2 (0.90) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL22822804 | 0.84 | SMN1; SMN2 (0.81) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL22822638 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL29467866 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL20767462 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL20767461 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL28707333 | 0.78 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL29467894 | 0.78 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL28862183 | 0.76 | TP53 (0.62) | SMN1; SMN2MAPTTP53ALDH1A1KDM4E | |
| SCHEMBL16291785 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTTP53TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395203-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. | 2021-12-23 | — | — | US | disclosed |
| US-20200399219-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399219-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | FKBP2, FKBP1B, FKBP1A | SMN1; SMN2 379/4885MAPT 204/4885TP53 2291/4885 |
| US-20210395203-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | FKBP2, FKBP1B, FKBP1A | SMN1; SMN2 379/4885MAPT 204/4885TP53 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.