Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 15/20 | 0.57 |
| ▸ | KDM5C | P41229 | 8/20 | 0.50 |
| ▸ | KDM5A | P29375 | 8/20 | 0.50 |
| ▸ | KDM4A | O75164 | 3/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.43 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19574653 | 0.90 | KDM5B (0.70) | KDM5BKDM5CKDM5AKDM4AKDM2B | |
| SCHEMBL15636990 | 0.89 | KDM5B (0.60) | KDM5BKDM5CKDM5AKDM4AKDM2B | |
| SCHEMBL16291869 | 0.85 | KDM5B (0.50) | KDM5BKDM5CKDM5AKDM4AKDM2B | |
| SCHEMBL28168442 | 0.77 | KDM5B (0.44) | KDM5BACKR3 | |
| SCHEMBL15994092 | 0.73 | KDM5B (0.42) | KDM5BKDM5CKDM5AKDM4AKDM2B | |
| SCHEMBL16006904 | 0.72 | ACKR3 (0.39) | KDM5BKDM5CKDM4AKDM4CKDM4B | |
| SCHEMBL19676466 | 0.72 | KDM5B (0.49) | KDM5BKDM5CKDM5AKDM4AKDM2B | |
| SCHEMBL19574682 | 0.72 | KDM5B (0.49) | KDM5BKDM5CKDM5AKDM4AKDM2B | |
| SCHEMBL16293306 | 0.70 | CHRM2 (0.55) | ACKR3KMT2A | |
| SCHEMBL15636266 | 0.69 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4AKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |