Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 1/20 | 0.69 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CCR5 | P51681 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8406943 | 0.88 | HTR1A (0.65) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL4680227 | 0.88 | USP28 (0.68) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL17197395 | 0.88 | CCR5 (0.62) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL27402118 | 0.86 | CCR5 (0.60) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL5210786 | 0.85 | CCR5 (0.63) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL6260325 | 0.85 | CCR5 (0.59) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL16293879 | 0.85 | CCR5 (0.59) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL16294058 | 0.84 | PTGER1 (0.64) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL7585417 | 0.84 | CCR5 (0.58) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL15196646 | 0.83 | CCR5 (0.63) | USP28USP25HTTALDH1A1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008052-A1 | MACROCYCLIC FACTOR VIIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014201073-A9 | MACROCYCLIC FACTOR VIIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-10-08 | — | — | WO | disclosed |
| WO-2014201073-A1 | MACROCYCLIC FACTOR VIIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-12-18 | — | — | WO | disclosed |