Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 16/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 15/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 13/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 8/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964882 | 0.74 | FGFR1 (0.53) | CYP1A2ALDH1A1CYP2C19LMNACLK4 | |
| SCHEMBL14965146 | 0.74 | KMT2A (0.42) | CYP3A4CYP1A2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL2368752 | 0.73 | PKM (0.53) | CYP3A4CYP1A2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL2369304 | 0.72 | CYP2A6 (0.51) | MAPK1CYP19A1 | |
| SCHEMBL2368808 | 0.69 | LMNA (0.55) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL29429633 | 0.69 | CA1 (0.71) | CYP3A4CYP1A2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL6754272 | 0.69 | CYP1A2 (0.54) | CYP3A4CYP1A2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL29788337 | 0.69 | CA1 (0.71) | CYP3A4CYP1A2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL174453 | 0.69 | CYP1A2 (0.54) | CYP3A4CYP1A2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL301996 | 0.69 | CA1 (0.71) | CYP3A4CYP1A2HSD17B10TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160152634-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2016-06-02 | — | — | US | disclosed |
| US-9290511-B2 | Thieno-pyrimidines, useful as potassium channel inhibitors | XENTION LIMITED (GB) | 2016-03-22 | — | — | US | disclosed |
| US-20140371203-A1 | Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors | XENTION LIMITED (GB) | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371203-A1 | Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors | KCNA3, KCNJ1, KCNJ11 | CYP3A4 682/4885CYP1A2 1211/4885HSD17B10 4161/4885 |
| US-20160152634-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | KCNA3, KCNJ1, KCNJ11 | CYP3A4 556/4885CYP1A2 1075/4885HSD17B10 4051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.