Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 8/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964882 | 0.78 | FGFR1 (0.53) | CYP2C19CYP1A2MAPK1LMNACLK4 | |
| SCHEMBL2368453 | 0.76 | PKM (0.51) | PKMCYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2369304 | 0.75 | CYP2A6 (0.51) | MAPK1MAPT | |
| SCHEMBL2367997 | 0.74 | LMNA (0.49) | PKMLMNACLK4ALDH1A1MAPT | |
| SCHEMBL16294249 | 0.73 | CYP3A4 (0.54) | CYP2C19CYP1A2CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL5376619 | 0.73 | MAPT (0.53) | MAPK1LMNAALDH1A1MAPTHPGD | |
| SCHEMBL2368915 | 0.71 | SMN1; SMN2 (0.38) | CYP2C19CYP1A2CYP3A4HSD17B10MAPK1 | |
| SCHEMBL30700550 | 0.71 | DHFR (0.41) | LMNACLK4ALDH1A1MAPTKDM4E | |
| SCHEMBL12599829 | 0.71 | PKM (0.60) | PKMHSD17B10MAPK1LMNACLK4 | |
| SCHEMBL12303147 | 0.71 | DYRK1A (0.55) | CYP2C19CYP1A2CYP3A4CYP2D6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |