Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309429 | 0.80 | KMT2A (0.65) | MAPTGFERALDH1A1PPARGGAA | |
| SCHEMBL5797850 | 0.79 | MAPT (0.50) | MAPTGFERALDH1A1S1PR4PPARG | |
| SCHEMBL10522426 | 0.79 | ALDH1A1 (0.77) | MAPTGFERALDH1A1GAAMEN1 | |
| SCHEMBL7023377 | 0.79 | ALDH1A1 (0.56) | MAPTGFERALDH1A1PPARGTDP1 | |
| SCHEMBL640965 | 0.79 | HPGD (0.73) | MAPTALDH1A1S1PR4SLC6A2SLC6A4 | |
| SCHEMBL30392319 | 0.79 | HPGD (0.73) | MAPTALDH1A1S1PR4SLC6A2SLC6A4 | |
| SCHEMBL3654191 | 0.76 | PDE7A (0.63) | MAPTALDH1A1S1PR4SLC6A2TDP1 | |
| SCHEMBL4007224 | 0.76 | SLC6A2 (0.55) | MAPTALDH1A1S1PR4HTR1ASLC6A2 | |
| SCHEMBL16294936 | 0.76 | SLC6A2 (0.55) | MAPTALDH1A1S1PR4HTR1ASLC6A2 | |
| SCHEMBL4965836 | 0.75 | MAPK1 (0.62) | MAPTS1PR4SLC6A2TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014199164-A1 | DIARYL SUBSTITUTED HETEROAROMATIC COMPOUNDS | AMPLA PHARMACEUTICALS, INC. (US) | 2014-12-18 | — | — | WO | disclosed |