Cytosine

Cytosine

SCHEMBL1629580

Nc1cc[nH]c(=O)n1.O=P(O)(O)O

nearest known ligand 0.38

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Cytosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
JAK2 known ✓ O60674 1/20 0.32
FGFR1 known ✓ P11362 1/20 0.30
DYRK1A Q13627 1/20 0.38
TSHR P16473 1/20 0.35
ADORA2A P29274 4/20 0.34
ADORA1 P30542 4/20 0.34
PRKCI P41743 1/20 0.33
RPS6KA3 P51812 1/20 0.32
MELK Q14680 1/20 0.32
STK24 Q9Y6E0 1/20 0.32
PLAU P00749 1/20 0.30
FDPS P14324 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cytosine SCHEMBL1144358 1.00 DYRK1A (0.38) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL76045 1.00 DYRK1A (0.38) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL10496353 1.00 DYRK1A (0.38) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL26123983 0.98 DYRK1A (0.37) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL29123329 0.94 TSHR (0.36) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL5356635 0.94 DYRK1A (0.37) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL28199181 0.93 DYRK1A (0.34) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL28004771 0.90 DYRK1A (0.37) DYRK1ATSHRADORA2AADORA1PRKCI
Cytosine SCHEMBL4059 0.89
Cytosine SCHEMBL1330400 0.89

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2154 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4703473-A1 NON-METHYLATED CPG OLIGODEOXYNUCLEOTIDE AND APPLICATION THEREOF Beijing Ray Medicine Biotechnology Co., Ltd. (CN) 2026-03-04 EP claimed
EP-4043017-B1 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS BIOMED VALLEY DISCOVERIES INC (US) 2026-01-28 EP claimed
US-20250391503-A1 APPLICATION OF GENE MARKERS IN MULTI-CANCER EARLY DETECTION, METHOD FOR CONSTRUCTING EARLY DETECTION MODEL, AND DETECTION DEVICE GENESEEQ TECHNOLOGY INC. (CA) 2025-12-25 US claimed
EP-4668277-A1 APPLICATION OF GENE MARKERS IN MULTI-CANCER EARLY DETECTION, METHOD FOR CONSTRUCTING EARLY DETECTION MODEL, AND DETECTION DEVICE Geneseeq Technology Inc. (CA) 2025-12-24 EP claimed
US-12458688-B2 Epitopes SCANCELL LIMITED (GB) 2025-11-04 US claimed
US-12427118-B2 Injectable cryogel vaccine devices and methods of use thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-09-30 US claimed
US-20250207202-A1 METHODS AND COMPOSITIONS FOR IDENTIFYING HOX GENE SIGNATURES TO ASSIGN SPECIFIC AND EFFECTIVE THERAPIES IN ACUTE MYELOID LEUKEMIA AND OTHER CANCERS OHIO STATE INNOVATION FOUNDATION 2025-06-26 US claimed
EP-4554628-A1 HIV IMMUNOGENIC POLYPEPTIDES AND VACCINES AND USES THEREOF GILEAD SCIENCES, INC. (US) 2025-05-21 EP claimed
US-12296002-B2 Immunogenic composition against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) MEDIGEN VACCINE BIOLOGICS CORPORATION (TW) 2025-05-13 US claimed
WO-2025076398-A1 IMMUNOMODULATORY NANOPARTICLE CONJUGATESAND USES THEREOF CORNELL UNIVERSITY (US) 2025-04-10 WO claimed
US-20120190631-A1 MATERIALS AND METHODS RELATING TO GLYCOSYLATION Iksuda Therapeutics Limited (GB) 2012-07-26 US claimed
US-8173620-B2 BHQ-caged nucleotide probes photolysable by two-photon excitation UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2012-05-08 US claimed
WO-2010146362-A2 MATERIALS AND METHODS RELATING TO GLYCOSYLATION THE UNIVERSITY OF BATH (GB) 2010-12-23 WO claimed
US-20100048502-A1 BHQ-CAGED NUCLEOTIDE PROBES PHOTOLYSABLE BY TWO-PHOTON EXCITATION NATIONAL SCIENCE FOUNDATION 2010-02-25 US claimed
US-20090264621-A1 Lipid-assisted synthesis of polymer compounds and methods for their use THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2009-10-22 US claimed
US-6982165-B2 Nucleic acid sequencing by raman monitoring of molecular deconstruction INTEL CORPORATION (US) 2006-01-03 US claimed
EP-1366010-A2 METHOD FOR PRODUCING VINYL, ARYL AND HETEROARYL ACETIC ACIDS AND DERIVATIVES THEREOF Studiengesellschaft Kohle mbH (DE) 2003-12-03 EP claimed
WO-2002072524-A2 METHOD FOR PRODUCING VINYL, ARYL AND HETEROARYL ACETIC ACIDS AND DERIVATIVES THEREOF STUDIENGESELLSCHAFT KOHLE MBH (DE) 2002-09-19 WO claimed
EP-0820520-B1 IMPROVED ENZYMATIC SYNTHESIS OF OLIGOSACCHARIDES NEOSE TECHNOLOGIES INC (US) 2002-08-14 EP claimed
US-5891452-A Cosmetic or dermatological composition containing at least one active principle precursor and a crosslinked poly(2-acrylamido-2-methylpropanesulphonic acid) polymer neutralized to at least 90% L'OREAL (FR) 1999-04-06 US claimed