Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Cytosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cytosine SCHEMBL10767383 | 0.93 | DYRK1A (0.38) | DYRK1ATSHRADORA2AADORA1F2 | |
| Cytosine SCHEMBL76045 | 0.93 | DYRK1A (0.38) | DYRK1ATSHRADORA2AADORA1PRKCI | |
| Cytosine SCHEMBL218676 | 0.93 | DYRK1A (0.38) | DYRK1ATSHRADORA2AADORA1F2 | |
| Cytosine SCHEMBL1144358 | 0.93 | DYRK1A (0.38) | DYRK1ATSHRADORA2AADORA1PRKCI | |
| Cytosine SCHEMBL10496353 | 0.93 | DYRK1A (0.38) | DYRK1ATSHRADORA2AADORA1PRKCI | |
| Cytosine SCHEMBL1629580 | 0.93 | DYRK1A (0.38) | DYRK1ATSHRADORA2AADORA1PRKCI | |
| Cytosine SCHEMBL29123329 | 0.91 | TSHR (0.36) | DYRK1ATSHRADORA2AADORA1PRKCI | |
| Cytosine SCHEMBL26123983 | 0.91 | DYRK1A (0.37) | DYRK1ATSHRADORA2AADORA1PRKCI | |
| Cytosine SCHEMBL5356635 | 0.87 | DYRK1A (0.37) | DYRK1ATSHRADORA2AADORA1PRKCI | |
| Cytosine SCHEMBL28004771 | 0.84 | DYRK1A (0.37) | DYRK1ATSHRADORA2AADORA1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107670032-A | The preparation method of poultry oil emulsion inactivated vaccine adjuvant and its corresponding vaccine | 贵州福斯特生物科技有限公司 | 2018-02-09 | — | — | CN | disclosed |