Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417913 | 0.92 | KDM4E (0.81) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL1081091 | 0.86 | LMNA (0.54) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL5185328 | 0.85 | KDM4E (0.77) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL10570426 | 0.82 | KDM4E (1.00) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL311900 | 0.80 | KDM4E (0.64) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL2114938 | 0.80 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL19659065 | 0.77 | KDM4E (0.56) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL10278987 | 0.77 | KDM4E (0.59) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL4957306 | 0.77 | KDM4E (0.59) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL22761420 | 0.76 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008067-A1 | 4-AMINO-6-PHENYL-5,6-DIHYDROIMIDAZO[1,5-A]PYRAZIN-3(2H)-ONE DERIVATIVES AS INHIBITORS OF BETA-SECRETASE (BACE) | Janssen Pharmaceutica N.V. (BE) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198851-A1 | 4-AMINO-6-PHENYL-5,6-DIHYDROIMIDAZO[1,5-A]PYRAZIN-3(2H)-ONE DERIVATIVES AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-18 | — | — | WO | disclosed |