Sugi Predict

Sugi Predict / Compounds / SCHEMBL2114938

SCHEMBL2114938

SCHEMBL2114938

CCOC(=O)c1nc[nH]c1C

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 6/20 0.63
▸ SMN1; SMN2 Q16637 1/20 0.55
▸ LMNA P02545 3/20 0.51
▸ ALDH1A1 P00352 5/20 0.50
▸ KMT2A Q03164 3/20 0.49
▸ MEN1 O00255 2/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ GAA P10253 3/20 0.48
▸ POLB P06746 1/20 0.48
▸ HPGD P15428 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ KDM5B Q9UGL1 1/20 0.46
▸ RXFP1 Q9HBX9 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ PDE4D Q08499 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11725688 0.85 LMNA (0.73) KDM4ESMN1; SMN2LMNAALDH1A1MAPK1
SCHEMBL1417913 0.84 KDM4E (0.81) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL4957306 0.82 KDM4E (0.59) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL10278987 0.82 KDM4E (0.59) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL311900 0.82 KDM4E (0.64) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL11796698 0.82 KDM4E (0.44) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL10552507 0.81 NPSR1 (0.46) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL5870445 0.81 KDM4E (0.58) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL1498373 0.81 KDM4E (0.58) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL5185328 0.81 KDM4E (0.77) KDM4ESMN1; SMN2LMNAALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4055573-A TO 4-HYDROXYMETHYL OR ALKOXYMETHYL IMIDAZOLES SMITHKLINE CORPORATION (US) 1977-10-25 — — US claimed
EP-4178620-B1 PLASMA KALLIKREIN INHIBITORS MERCK SHARP & DOHME LLC (US) 2026-04-01 — — EP disclosed
US-20260085048-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF EPIVARIO INC (US) 2026-03-26 — — US disclosed
EP-4709374-A2 KCC2 POTENTIATORS AND USES THEREOF Axonis Therapeutics, Inc. (US) 2026-03-18 — — EP disclosed
US-20260062402-A1 KCC2 POTENTIATORS AND USES THEREOF AXONIS THERAPEUTICS INC (US) 2026-03-05 — — US disclosed
US-12528786-B2 Plasma kallikrein inhibitors MERCK SHARP & DOHME LLC (US) 2026-01-20 — — US disclosed
US-12441689-B2 ACSS2 inhibitors and methods of use thereof EPIVARIO, INC. (US) 2025-10-14 — — US disclosed
US-20250179061-A1 RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2025-06-05 — — US disclosed
EP-4540238-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME Monte Rosa Therapeutics AG (CH) 2025-04-23 — — EP disclosed
US-20250115582-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME MONTE ROSA THERAPEUTICS AG (CH) 2025-04-10 — — US disclosed
EP-0189458-A1 IMIDAZOLE PLANT GROWTH REGULATORS FMC Corporation (US) 1986-08-06 — — EP disclosed
US-4565875-A Imidazole plant growth regulators FMC CORPORATION (US) 1986-01-21 — — US disclosed
WO-1986000305-A1 IMIDAZOLE PLANT GROWTH REGULATORS FMC CORPORATION (US) 1986-01-16 — — WO disclosed
US-4432983-A GASTRIC ACID INHIBITORS RESEARCH CORPORATION (US) 1984-02-21 — — US disclosed
US-4374252-A Benzyl 5-methyl-4-imidazolecarboxylate SK&F LAB CO. (US) 1983-02-15 — — US disclosed
US-4328349-A Process for preparing 5-methyl-4-imidazolecarboxylic acid esters SK&F LAB CO. (US) 1982-05-04 — — US disclosed
EP-0049638-A1 Process for prepararing 5-methyl-4-imidazolecarboxylic acid esters SMITHKLINE BECKMAN CORPORATION (US) 1982-04-14 — — EP disclosed
EP-0008596-A1 Preparation of 4-hydroxymethyl-imidazole derivatives from the corresponding 4-imidazole carboxylic acid esters DEVINTER Europe S.A. Société anonyme dite: (BE) 1980-03-19 — — EP disclosed
US-4063023-A Process for preparing 4-(hydroxymethyl)imidazole compounds SK&F LAB CO. (US) 1977-12-13 — — US disclosed
US-4055573-A TO 4-HYDROXYMETHYL OR ALKOXYMETHYL IMIDAZOLES SMITHKLINE CORPORATION (US) 1977-10-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179061-A1 RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF RIPK1, RIPK2, RIPK3 KDM4E 3746/4885SMN1; SMN2 1610/4885LMNA 2266/4885
US-12528786-B2 Plasma kallikrein inhibitors CFH, KLKB1, SERPINH1 KDM4E 998/4885SMN1; SMN2 4232/4885LMNA 935/4885
US-20260085048-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF ACSS2, GLS2, ACSL3 KDM4E 1262/4885SMN1; SMN2 4460/4885LMNA 2111/4885
US-12441689-B2 ACSS2 inhibitors and methods of use thereof ACSS2, ADSS2, GLS2 KDM4E 1691/4885SMN1; SMN2 4463/4885LMNA 3750/4885
US-20250115582-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME PSMA1, CSNK1G1, CSNK1A1 KDM4E 394/4885SMN1; SMN2 2275/4885LMNA 1692/4885
US-20260062402-A1 KCC2 POTENTIATORS AND USES THEREOF HCN2, HCN1, HCN4 KDM4E 2478/4885SMN1; SMN2 184/4885LMNA 1676/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.