Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 13/20 | 1.00 |
| ▸ | REN | P00797 | 4/20 | 0.74 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17764785 | 1.00 | CTSD (1.00) | CTSDRENPSEN1PSEN2APH1B | |
| SCHEMBL28464725 | 1.00 | CTSD (1.00) | CTSDRENPSEN1PSEN2APH1B | |
| SCHEMBL16296348 | 1.00 | CTSD (1.00) | CTSDRENPSEN1PSEN2APH1B | |
| SCHEMBL20725219 | 1.00 | CTSD (1.00) | CTSDRENPSEN1PSEN2APH1B | |
| SCHEMBL19696398 | 0.87 | CTSD (1.00) | CTSD | |
| SCHEMBL17770715 | 0.87 | CTSD (1.00) | CTSD | |
| SCHEMBL16312218 | 0.86 | CTSD (0.84) | CTSDREN | |
| SCHEMBL17764793 | 0.86 | CTSD (0.84) | CTSDREN | |
| SCHEMBL17764792 | 0.86 | CTSD (0.84) | CTSDREN | |
| SCHEMBL16296293 | 0.85 | CTSD (1.00) | CTSDREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160145297-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2016-05-26 | — | — | US | claimed |
| EP-3008037-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | Merck Patent GmbH (DE) | 2016-04-20 | — | — | EP | claimed |
| WO-2014198372-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2014-12-18 | — | — | WO | claimed |
| US-10202418-B2 | Hydroxy-ethylene derivatives for the treatment of arthrosis | MERCK PATENT GMBH (DE) | 2019-02-12 | — | — | US | disclosed |
| US-10202418-B2 | Hydroxy-ethylene derivatives for the treatment of arthrosis | MERCK PATENT GMBH (DE) | 2019-02-12 | — | — | US | disclosed |
| EP-3008037-B1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2018-09-26 | — | — | EP | disclosed |
| US-20160145297-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2016-05-26 | — | — | US | disclosed |
| US-20160145297-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2016-05-26 | — | — | US | disclosed |
| US-20160145297-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2016-05-26 | — | — | US | disclosed |
| EP-3008037-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | Merck Patent GmbH (DE) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198372-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2014-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202418-B2 | Hydroxy-ethylene derivatives for the treatment of arthrosis | CTSD, CTSE, CTSB | CTSD 1/4885REN 3041/4885PSEN1 2804/4885 |
| US-20160145297-A1 | HYDROXY-ETHYLENE DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | CTSD, CTSE, CTSB | CTSD 1/4885REN 3041/4885PSEN1 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.