Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.67 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.67 |
| ▸ | AR | P10275 | 6/20 | 0.65 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1631091 | 0.87 | PGR (0.73) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630736 | 0.84 | PGR (0.63) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630662 | 0.83 | PGR (0.60) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629636 | 0.83 | PGR (0.66) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1633786 | 0.83 | PGR (0.68) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630535 | 0.83 | PGR (0.62) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629259 | 0.83 | PGR (0.62) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1631048 | 0.83 | PGR (0.74) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630826 | 0.83 | PGR (0.74) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630932 | 0.83 | PGR (0.65) | PGRNR3C1NR3C2ARBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |