Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 11/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763677 | 0.91 | LMNA (0.57) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL8404478 | 0.89 | SIRT1 (0.55) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL8402724 | 0.89 | KIF11 (0.55) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL763586 | 0.88 | KIF11 (0.58) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL11912523 | 0.88 | KIF11 (0.58) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL12589746 | 0.88 | MAPT (0.54) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL764759 | 0.87 | ABCG2 (0.58) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL764291 | 0.87 | TP53 (0.61) | KIF11MAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL763417 | 0.87 | KIF11 (0.60) | KIF11MAPTTP53MEN1LMNA | |
| SCHEMBL763522 | 0.87 | KIF11 (0.53) | KIF11MAPTTP53SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |