Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KIF11 | P52732 | 8/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403179 | 0.87 | KIF11 (0.47) | TP53KIF11ABCG2ABCB1MAPT | |
| SCHEMBL8404494 | 0.83 | MAPT (0.46) | TP53KIF11ABCG2MAPTSMN1; SMN2 | |
| SCHEMBL8403149 | 0.82 | LMNA (0.50) | TP53KIF11MAPTSMN1; SMN2LMNA | |
| SCHEMBL8403206 | 0.82 | ATM (0.49) | KIF11MAPTSMN1; SMN2KDM4E | |
| SCHEMBL763597 | 0.81 | MAPT (0.46) | TP53KIF11ABCG2MAPTSMN1; SMN2 | |
| SCHEMBL763417 | 0.81 | KIF11 (0.60) | TP53KIF11ABCG2ABCB1MAPT | |
| SCHEMBL763677 | 0.81 | LMNA (0.57) | TP53KIF11ABCG2MAPTSMN1; SMN2 | |
| SCHEMBL12835223 | 0.81 | MAPT (0.46) | TP53KIF11ABCG2MAPTSMN1; SMN2 | |
| SCHEMBL8403215 | 0.81 | LMNA (0.49) | TP53KIF11MAPTSMN1; SMN2LMNA | |
| SCHEMBL8403113 | 0.81 | ALDH1A1 (0.50) | TP53KIF11ABCG2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |