Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 13/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30857635 | 1.00 | CHRM1 (0.49) | CHRM1CHRM3CHRM2CHRM4SLC6A4 | |
| SCHEMBL15920348 | 0.88 | HTR3E (0.52) | CHRM1CHRM3CHRM2CHRM4SLC6A4 | |
| SCHEMBL10175121 | 0.85 | SLC6A4 (0.51) | SLC6A4SLC6A3KDM2BMGLL | |
| SCHEMBL3709504 | 0.80 | HTR3E (0.56) | CHRM1SLC6A4SLC6A3HTR3EHTR3B | |
| Bromide SCHEMBL11199812 | 0.79 | HTR3E (0.55) | CHRM1SLC6A4SLC6A3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL3714989 | 0.79 | HTR3E (0.55) | CHRM1SLC6A4SLC6A3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL27265396 | 0.78 | HTR3E (0.49) | CHRM1CHRM3CHRM2CHRM4SLC6A4 | |
| SCHEMBL227983 | 0.77 | ALDH1A1 (0.50) | CHRM1CHRM3CHRM2CHRM4SLC6A4 | |
| SCHEMBL16818201 | 0.76 | CHRM1 (0.49) | CHRM1CHRM3CHRM2CHRM4HTR3E | |
| SCHEMBL654532 | 0.75 | MEN1 (0.67) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601177-B1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2017-10-18 | — | — | EP | disclosed |
| WO-2012017251-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |