Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.57 |
| ▸ | KDM5C | P41229 | 1/20 | 0.57 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28375714 | 0.97 | ALDH1A1 (0.64) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL49856 | 0.97 | ALDH1A1 (0.62) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL28219205 | 0.97 | ALDH1A1 (0.62) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| Ammonia Solution, Strong SCHEMBL15129241 | 0.94 | ALDH1A1 (0.60) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL219713 | 0.94 | ALDH1A1 (0.67) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL466559 | 0.94 | ALDH1A1 (0.67) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL4187314 | 0.94 | KDM4E (0.65) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL4186692 | 0.94 | ALDH1A1 (0.67) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL10396767 | 0.94 | ALDH1A1 (0.67) | ALDH1A1KDM4ECTSDKDM5CPHF8 | |
| SCHEMBL9007204 | 0.94 | ALDH1A1 (0.60) | ALDH1A1KDM4ECTSDKDM5CPHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859523-B2 | Crosslinked compounds and methods of making and using thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-10-14 | — | — | US | disclosed |
| EP-1539799-B1 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | UNIV UTAH RES FOUND (US) | 2013-12-11 | — | — | EP | disclosed |
| US-7928069-B2 | Crosslinked compounds and methods of making and using thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-04-19 | — | — | US | disclosed |
| US-20090117078-A1 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090105193-A1 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2009-04-23 | — | — | US | disclosed |
| EP-1539799-A4 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | UNIV UTAH RES FOUND (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20050176620-A1 | crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one tbiol compound with at least one thiol-reactive compound. | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-08-11 | — | — | US | disclosed |
| EP-1539799-A2 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | The University of Utah Research Foundation (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004037164-A2 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2004-05-06 | — | — | WO | disclosed |
| EP-1305355-A1 | HYDROGEL FILMS AND METHODS OF MAKING AND USING THEREFOR | The University of Utah Research Foundation (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002006373-A1 | HYDROGEL FILMS AND METHODS OF MAKING AND USING THEREFOR | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090117078-A1 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | APEX1, GPX4, LIG4 | ALDH1A1 399/4885KDM4E 1727/4885CTSD 1873/4885 |
| US-20090105193-A1 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | APEX1, GPX4, MGMT | ALDH1A1 469/4885KDM4E 1791/4885CTSD 2030/4885 |
| US-20050176620-A1 | crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one tbiol compound with at least one thiol-reactive compound. | TXN2, APEX1, MGMT | ALDH1A1 1151/4885KDM4E 3930/4885CTSD 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.