Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636348 | 0.78 | KDM4E (0.60) | ACKR3LTA4HKDM4EALDH1A1 | |
| SCHEMBL12803104 | 0.78 | GAA (0.63) | ACKR3LTA4HGAA | |
| SCHEMBL10153803 | 0.76 | SIGMAR1 (0.54) | ACKR3LTA4H | |
| SCHEMBL27997282 | 0.75 | KDM4E (0.61) | KDM4EACHEALDH1A1GAACYP2D6 | |
| SCHEMBL15800060 | 0.75 | HDAC1 (0.52) | KDM4EACHEALDH1A1CYP2D6MCHR1 | |
| SCHEMBL28577080 | 0.74 | KDM4E (0.60) | KDM4EACHEALDH1A1GAACYP2D6 | |
| SCHEMBL28572335 | 0.74 | KDM4E (0.60) | KDM4EACHEALDH1A1GAACYP2D6 | |
| SCHEMBL15800205 | 0.74 | KDM4E (0.67) | KDM4EACHEALDH1A1GAA | |
| SCHEMBL14402457 | 0.73 | KDM4E (0.57) | ACKR3KDM4EACHEALDH1A1GAA | |
| SCHEMBL28914380 | 0.73 | KDM4E (0.59) | KDM4EACHEALDH1A1CYP2D6MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912334-B2 | Biphenyl compounds useful as muscarinic receptor antagonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-12-16 | — | — | US | disclosed |