Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12803104 | 0.85 | GAA (0.63) | LTA4HACKR3 | |
| SCHEMBL10153803 | 0.83 | SIGMAR1 (0.54) | LTA4HSIGMAR1ACKR3 | |
| SCHEMBL4591716 | 0.83 | ALDH1A1 (0.67) | KDM4EALDH1A1SIGMAR1TNIK | |
| SCHEMBL24770743 | 0.82 | ALDH1A1 (0.65) | KDM4EALDH1A1LTA4HSIGMAR1TNIK | |
| SCHEMBL4592012 | 0.81 | KDM4E (0.63) | KDM4EALDH1A1LTA4HSIGMAR1TNIK | |
| SCHEMBL4591633 | 0.81 | SIGMAR1 (0.65) | KDM4EALDH1A1SIGMAR1TNIK | |
| SCHEMBL4591727 | 0.80 | KDM4E (0.70) | KDM4EALDH1A1LTA4HSIGMAR1ACKR3 | |
| SCHEMBL18291379 | 0.80 | KMT2A (0.54) | LTA4HACKR3 | |
| SCHEMBL16307192 | 0.78 | ACKR3 (0.52) | KDM4EALDH1A1LTA4HACKR3 | |
| SCHEMBL24771303 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1LTA4HSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754095-B2 | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2014-06-17 | — | — | US | disclosed |
| US-8754095-B2 | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2014-06-17 | — | — | US | disclosed |
| US-8754095-B2 | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2014-06-17 | — | — | US | disclosed |
| EP-2569297-A1 | SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-20 | — | — | EP | disclosed |
| US-20130059891-A1 | SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-07 | — | — | US | disclosed |
| US-20130059891-A1 | SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-07 | — | — | US | disclosed |
| US-20130059891-A1 | SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-07 | — | — | US | disclosed |
| WO-2011143161-A1 | SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-17 | — | — | WO | disclosed |
| WO-2011143161-A1 | SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059891-A1 | SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | HRH3, HRH4, HRH1 | KDM4E 1352/4885ALDH1A1 1436/4885LTA4H 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.