Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.52 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.52 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.52 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10759830 | 0.90 | CES2 (0.62) | AKR1C3ALDH1A1LMNATDP1GAA | |
| SCHEMBL11189754 | 0.86 | AKR1C3 (0.84) | AKR1C3ALDH1A1LMNATDP1CES2 | |
| SCHEMBL1631863 | 0.85 | AKR1C3 (0.56) | AKR1C3ALDH1A1LMNATDP1GAA | |
| SCHEMBL9507199 | 0.84 | CDC25B (0.60) | AKR1C3ALDH1A1LMNATDP1GAA | |
| SCHEMBL29377967 | 0.84 | CES2 (0.56) | AKR1C3ALDH1A1LMNATDP1GAA | |
| SCHEMBL896769 | 0.84 | CES2 (0.56) | AKR1C3ALDH1A1LMNATDP1GAA | |
| SCHEMBL333008 | 0.84 | AKR1C3 (0.61) | AKR1C3ALDH1A1LMNATDP1GAA | |
| SCHEMBL29433447 | 0.84 | AKR1C3 (0.61) | AKR1C3ALDH1A1LMNATDP1GAA | |
| SCHEMBL9409836 | 0.82 | CES2 (0.54) | ALDH1A1LMNATDP1GAAABCC9 | |
| Methylamine SCHEMBL10828909 | 0.82 | GAA (0.57) | AKR1C3ALDH1A1LMNATDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470872-B2 | Compounds with activity at estrogen receptors | ACADIA PHARMACEUTICALS INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120088825-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-8101651-B2 | Compounds with activity at estrogen receptors | ACADIA PHARMACEUTICALS INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20090131510-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. | 2009-05-21 | — | — | US | disclosed |
| EP-0628064-B2 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-0628064-B1 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5585042-A | REVERSIBLE CHANGE IN COLOR WHEN EXPOSURED TO ULTRAVIOLET RADIATION | TRANSITIONS OPTICAL, INC. (US) | 1996-12-17 | — | — | US | disclosed |
| EP-0628064-A4 | PHOTOCHROMIC NAPHTHOPYRANS. | PPG INDUSTRIES INC (US) | 1995-02-08 | — | — | EP | disclosed |
| EP-0628064-A1 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1994-12-14 | — | — | EP | disclosed |
| US-5369158-A | And polymer | TRANSITIONS OPTICAL, INC. (US) | 1994-11-29 | — | — | US | disclosed |
| EP-0600318-A1 | Asymmetric, halogenated benzophenones and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-08 | — | — | EP | disclosed |
| US-5300693-A | Process for the preparation of 1,4-bis(4-fluorobenzoyl)-benzene | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| WO-1993017071-A1 | PHOTOCHROMIC NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1993-09-02 | — | — | WO | disclosed |
| US-5238981-A | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0531339-A1 | PROCESS FOR PRODUCING 1,4-BIS-(FLUORBENZOYL)-BENZOL | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-17 | — | — | EP | disclosed |
| WO-1991018862-A1 | PROCESS FOR PRODUCING 1,4-BIS-(FLUORBENZOYL)-BENZOL | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088825-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ESRRB, ESR2, ESRRA | AKR1C3 613/4885ALDH1A1 566/4885LMNA 2718/4885 |
| US-20090131510-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ESRRB, ESR2, ESRRA | AKR1C3 613/4885ALDH1A1 566/4885LMNA 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.