Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24080619 | 0.98 | CASP2 (0.47) | CASP2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL31758445 | 0.98 | CASP2 (0.47) | CASP2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL24080628 | 0.98 | CASP2 (0.47) | CASP2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29756956 | 0.83 | FAAH (0.59) | CASP2PSMB5FAAHRECQLGAA | |
| SCHEMBL18649459 | 0.83 | FAAH (0.64) | CASP2PSMB5FAAHGAA | |
| SCHEMBL23718659 | 0.83 | FAAH (0.59) | CASP2PSMB5FAAHRECQLGAA | |
| SCHEMBL24095793 | 0.83 | FAAH (0.64) | CASP2PSMB5FAAHGAA | |
| SCHEMBL42695 | 0.82 | — | — | |
| SCHEMBL31758434 | 0.81 | CASP2 (0.59) | CASP2FAAH | |
| SCHEMBL17676463 | 0.81 | FAAH (0.56) | CASP2HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023088427-A1 | SIRNA TARGETING ANGIOTENSINOGEN AND PHARMACEUTICAL USE OF SIRNA | 上海拓界生物医药科技有限公司 | 2023-05-25 | — | — | WO | disclosed |
| EP-4006028-A1 | IRAK4 KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | Zhuhai Yufan Biotechnologies Co., Ltd (CN) | 2022-06-01 | — | — | EP | disclosed |
| WO-2017121649-A1 | 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2017-07-20 | — | — | WO | disclosed |
| WO-2016008582-A1 | SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2016-01-21 | — | — | WO | disclosed |
| US-8911967-B2 | One pot desialylation and glycopegylation of therapeutic peptides | NOVO NORDISK A/S (DK) | 2014-12-16 | — | — | US | disclosed |