SCHEMBL16309508

SCHEMBL16309508

Cc1ccc(/C=C/[SiH2]c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.44
MAPT P10636 2/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP3A4 P08684 1/20 0.44
NFE2L2 Q16236 4/20 0.43
TRPM8 Q7Z2W7 2/20 0.41
CYP1B1 Q16678 1/20 0.41
FGF23 Q9GZV9 1/20 0.40
RELA Q04206 1/20 0.39
CA1 P00915 1/20 0.39
KDM4E B2RXH2 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
LMNA P02545 1/20 0.39
TSHR P16473 1/20 0.39
ALOX12 P18054 1/20 0.39
ACHE P22303 1/20 0.39
FOS P01100 1/20 0.38
JUN P05412 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8080827 0.85 MAOB (0.48) MAPTALDH1A1NFE2L2RELACA1
SCHEMBL17862087 0.85 MAOB (0.48) MAPTALDH1A1NFE2L2RELACA1
SCHEMBL31296020 0.82 CA1 (0.47) MAPTALDH1A1CYP3A4NFE2L2CA1
SCHEMBL17862089 0.80 NFE2L2 (0.59) MAPTALDH1A1NFE2L2TSHREGFR
SCHEMBL31296017 0.79 PTGS1 (0.46) HPGDMAPTALDH1A1RELAKDM4E
SCHEMBL700269 0.75 NFE2L2 (0.61) HPGDMAPTALDH1A1CYP3A4NFE2L2
SCHEMBL4585859 0.75 NFE2L2 (0.61) HPGDMAPTALDH1A1CYP3A4NFE2L2
SCHEMBL4585865 0.75 NFE2L2 (0.61) HPGDMAPTALDH1A1CYP3A4NFE2L2
SCHEMBL1239547 0.75 NFE2L2 (0.61) HPGDMAPTALDH1A1CYP3A4NFE2L2
SCHEMBL4585867 0.75 NFE2L2 (0.61) HPGDMAPTALDH1A1CYP3A4NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014201082-A1 FIRST-ROW TRANSITION METAL HYDROGENATION AND HYDROSILYLATION CATALYSTS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2014-12-18 WO disclosed