Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL21569378 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL31673494 | 0.97 | — | — | |
| Malic Acid SCHEMBL856 | 0.97 | — | — | |
| Malic Acid SCHEMBL29410671 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL89131 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL31673489 | 0.97 | — | — | |
| Malic Acid SCHEMBL98496 | 0.97 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL256122 | 0.97 | — | — | |
| Malic Acid SCHEMBL30036890 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100390251-C | Preparation of curcas biological diesel oil by solid phase catalytic method | UNIV GUIZHOU (CN) | 2008-05-28 | — | — | CN | claimed |
| CN-1824735-A | Preparation of curcas biological diesel oil by solid phase catalytic method | UNIV GUIZHOU (CN) | 2006-08-30 | — | — | CN | claimed |
| EP-0478199-B1 | Polyvinyl chloride resin composition for powder molding | SUMITOMO CHEMICAL CO (JP) | 1997-06-25 | — | — | EP | claimed |
| EP-0478199-A2 | Polyvinyl chloride resin composition for powder molding | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-04-01 | — | — | EP | claimed |
| CN-1012682-B | POLYVINYL CHLORIDE RESIN COMPOSITION FOR POWDER MOLDING | SUMITOMO CHEMICAL CO (JP) | 1991-05-29 | — | — | CN | claimed |
| US-4861816-A | Polyvinyl chloride resin composition for powder molding | SUMITOMO CHEMICAL COMPANY (JP) | 1989-08-29 | — | — | US | claimed |
| CN-87105970-A | The poly (vinyl chloride) resin composition that is used for powder molding | — | 1988-08-10 | — | — | CN | claimed |
| US-12594345-B2 | Degradable hyaluronic acid hydrogels | ASCENDIS PHARMA A/S (DK) | 2026-04-07 | — | — | US | disclosed |
| WO-2024225268-A1 | PEROVSKITE COMPOUND AND METHOD FOR PRODUCING SAME | 堺化学工業株式会社 | 2024-10-31 | — | — | WO | disclosed |
| CN-110366597-B | Blood profiling with protease inhibitors | 善威生物私人有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-20240060997-A1 | Blood Preparation and Profiling | SANGUI BIO PTY LTD (AU) | 2024-02-22 | — | — | US | disclosed |
| US-11693006-B2 | Blood profiling with protease inhibitors | SANGUI BIO PTY. LTD (AU) | 2023-07-04 | — | — | US | disclosed |
| EP-4009047-A1 | BLOOD PREPARATION AND PROFILING | Sangui Bio Pty. Ltd (AU) | 2022-06-08 | — | — | EP | disclosed |
| EP-0478199-A2 | Polyvinyl chloride resin composition for powder molding | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-04-01 | — | — | EP | disclosed |
| CN-1012682-B | POLYVINYL CHLORIDE RESIN COMPOSITION FOR POWDER MOLDING | SUMITOMO CHEMICAL CO (JP) | 1991-05-29 | — | — | CN | disclosed |
| US-4861816-A | Polyvinyl chloride resin composition for powder molding | SUMITOMO CHEMICAL COMPANY (JP) | 1989-08-29 | — | — | US | disclosed |
| CN-87105970-A | The poly (vinyl chloride) resin composition that is used for powder molding | — | 1988-08-10 | — | — | CN | disclosed |
| US-4234516-A | Method of isomerizing humulone to isohumulone by catalytic acceleration with metal salts | ATLANTIC RESEARCH INSTITUTE LIMITED (BS) | 1980-11-18 | — | — | US | disclosed |
| US-4128691-A | ELECTROLESS PLATING | FUJI PHOTO FILM CO., LTD. (JP) | 1978-12-05 | — | — | US | disclosed |
| US-3952061-A | Method of isomerizing humulone to isohumulone by catalytic acceleration with metal salts | ATLANTIC RESEARCH INSTITUTE LIMITED (BA) | 1976-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12594345-B2 | Degradable hyaluronic acid hydrogels | CD44, H1-0, MMP1 | SMN1; SMN2 2664/4885SLC22A6 714/4885TET2 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.