Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 8/20 | 0.64 |
| ▸ | CA1 | P00915 | 8/20 | 0.64 |
| ▸ | CA2 | P00918 | 8/20 | 0.64 |
| ▸ | CA9 | Q16790 | 8/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22640129 | 0.84 | KDM4E (0.71) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL22639981 | 0.84 | KDM4E (0.71) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL6259021 | 0.84 | CA12 (0.61) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL5390387 | 0.83 | PTGS1 (0.74) | KDM4EADRB1ADRB2ADRB3PTGS1 | |
| SCHEMBL13357760 | 0.83 | ADRB3 (0.60) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL7934862 | 0.83 | MAPT (0.55) | CA1CA2CA9KDM4EADRB1 | |
| SCHEMBL5354594 | 0.83 | CA12 (0.60) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL16090435 | 0.82 | ADRB1 (0.70) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL6262690 | 0.82 | ADRB1 (0.70) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL6786842 | 0.82 | ADRB2 (0.59) | ADRB1ADRB2ADRB3PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298304-A2 | Carboline derivatives useful in the treatment of cancer | PTC Therapeutics, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |