Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319070 | 1.00 | PTGER4 (0.55) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL9857590 | 0.91 | PTGER1 (0.67) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL15668890 | 0.90 | HDAC8 (0.52) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL15668889 | 0.90 | HDAC8 (0.52) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL19511203 | 0.86 | PTGER4 (0.60) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL19511202 | 0.86 | PTGER4 (0.60) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL29191491 | 0.83 | PTGER4 (0.53) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL16852753 | 0.83 | KDM4E (0.55) | MAPTL3MBTL1LMNAKDM4EALDH1A1 | |
| SCHEMBL19511425 | 0.82 | PTGER4 (0.47) | PTGER4PTGER2PTGER3PTGER1HDAC8 | |
| SCHEMBL19511423 | 0.82 | PTGER4 (0.47) | PTGER4PTGER2PTGER3PTGER1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181186-B2 | Aromatic ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-11-10 | — | — | US | disclosed |
| US-20150045378-A1 | AROMATIC RING COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-02-12 | — | — | US | disclosed |
| EP-2816032-A1 | AROMATIC RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2014-12-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045378-A1 | AROMATIC RING COMPOUND | GPR119, GPR27, GPR4 | PTGER4 364/4885PTGER2 1127/4885PTGER3 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.