Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 5/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1690268 | 0.82 | SCN9A (0.55) | — | |
| SCHEMBL365692 | 0.80 | LMNA (0.48) | CSF1RLMNAHTTPARP10PARP14 | |
| SCHEMBL16319179 | 0.78 | HTT (0.47) | CSF1RLMNAHTTPARP10PARP14 | |
| SCHEMBL16319445 | 0.77 | SLC6A2 (0.49) | CSF1RTDP1LMNAHTTPARP10 | |
| SCHEMBL16319558 | 0.77 | SCN9A (0.43) | CSF1RLMNAHTTPARP10PARP14 | |
| SCHEMBL16319728 | 0.75 | SCN8A (0.44) | LMNAHTT | |
| SCHEMBL607011 | 0.75 | MKNK1 (0.57) | MKNK1MKNK2IKBKBCHUKSIRT3 | |
| SCHEMBL3966553 | 0.75 | SIRT3 (0.59) | MKNK1MKNK2IKBKBCHUKSIRT3 | |
| SCHEMBL29617706 | 0.75 | SIRT3 (0.59) | MKNK1MKNK2IKBKBCHUKSIRT3 | |
| SCHEMBL16174914 | 0.75 | SLC22A12 (0.43) | CLK1CLK2CLK3CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593432-B1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LTD (GB) | 2014-10-22 | — | — | EP | disclosed |