SCHEMBL16319558

SCHEMBL16319558

COc1cc(Cl)c(Cl)cc1Oc1cc(F)c(C(N)=O)cc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.43
LMNA P02545 1/20 0.42
HTT P42858 1/20 0.42
CSF1R P07333 5/20 0.40
PARP14 Q460N5 1/20 0.39
PARP10 Q53GL7 1/20 0.39
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
NPC1 O15118 2/20 0.39
MAPT P10636 2/20 0.39
RAB9A P51151 2/20 0.39
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
NUDT1 P36639 1/20 0.38
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38
SLC6A2 P23975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16319445 0.86 SLC6A2 (0.49) SCN9ALMNAHTTCSF1RPARP14
SCHEMBL365692 0.83 LMNA (0.48) LMNAHTTCSF1RPARP14PARP10
SCHEMBL16319179 0.82 HTT (0.47) LMNAHTTCSF1RPARP14PARP10
SCHEMBL28143231 0.81 PARP10 (0.48) LMNAHTTCSF1RPARP14PARP10
SCHEMBL16319797 0.79 SCN9A (0.69) SCN9ASCN8ASCN10A
SCHEMBL16319728 0.79 SCN8A (0.44) LMNAHTTMAPTRAB9ASCN8A
SCHEMBL3347725 0.79 NPC1 (0.47) LMNAHTTCSF1RPARP14PARP10
SCHEMBL16175331 0.77 MKNK1 (0.45) LMNAHTTCSF1RPARP14PARP10
SCHEMBL365684 0.76 SCN10A (0.47) SCN9ALMNAHTTPARP14PARP10
SCHEMBL6736165 0.74 PARP10 (0.48) LMNAHTTCSF1RPARP14PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593427-B1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LTD (GB) 2014-12-24 EP disclosed