Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.59 |
| ▸ | SCN1A | P35498 | 2/20 | 0.59 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.59 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.59 |
| ▸ | SCN2B | O60939 | 1/20 | 0.50 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319636 | 0.81 | SCN9A (0.48) | SCN9ACYP2C9SCN5ASCN1ASCN2A | |
| SCHEMBL16319452 | 0.78 | SCN9A (0.66) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL28126670 | 0.75 | SCN9A (0.65) | SCN9ACYP2C9SCN5ASCN1ASCN2A | |
| SCHEMBL16240247 | 0.75 | MRGPRX4 (0.55) | SCN9ACYP2C9SCN5A | |
| Pf-05186462 SCHEMBL1094900 | 0.74 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN1ASCN2A | |
| SCHEMBL16531653 | 0.74 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN1ASCN2A | |
| Pf-05186462 SCHEMBL30275377 | 0.74 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN1ASCN2A | |
| SCHEMBL16531719 | 0.74 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN1ASCN2A | |
| SCHEMBL16320077 | 0.73 | SCN9A (0.62) | SCN9ASCN5A | |
| SCHEMBL17940222 | 0.72 | SCN9A (1.00) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |