Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239759 | 0.86 | LRRK2 (0.51) | MRGPRX4LRRK2RXRARXRBRXRG | |
| SCHEMBL16319636 | 0.85 | SCN9A (0.48) | SCN9ASCN5ACYP2C9FPR2 | |
| SCHEMBL16240249 | 0.85 | RXRA (0.63) | MRGPRX4LRRK2RXRARXRBRXRG | |
| SCHEMBL1104996 | 0.79 | LRRK2 (0.61) | MRGPRX4LRRK2RXRARXRBRXRG | |
| SCHEMBL16319247 | 0.75 | SCN9A (0.59) | SCN9ASCN5ACYP2C9 | |
| SCHEMBL1101410 | 0.75 | LRRK2 (0.53) | MRGPRX4LRRK2RXRARXRBRXRG | |
| SCHEMBL10237075 | 0.71 | MRGPRX4 (0.49) | MRGPRX4RXRARXRBRXRGSCN9A | |
| SCHEMBL1104997 | 0.71 | SCN9A (0.48) | SCN9ASCN5APTGDR2CYP2C9FPR2 | |
| SCHEMBL22481025 | 0.71 | MRGPRX4 (1.00) | MRGPRX4 | |
| SCHEMBL14900608 | 0.70 | MRGPRX4 (0.53) | MRGPRX4SCN9APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |