Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16240247 | 0.85 | MRGPRX4 (0.55) | SCN9AFPR2CYP2C9SCN5A | |
| SCHEMBL16319247 | 0.81 | SCN9A (0.59) | SCN9ACYP2C9SCN5ASCN1ASCN2A | |
| SCHEMBL16242178 | 0.79 | SCN9A (0.57) | SCN9ASCN5A | |
| SCHEMBL16242166 | 0.77 | SCN9A (0.55) | SCN9AKDM4EMAPTCYP2C9SCN5A | |
| SCHEMBL680488 | 0.76 | MRGPRX4 (0.54) | SCN9AKDM4EMAPTSCN5A | |
| SCHEMBL15094018 | 0.76 | SCN9A (0.47) | SCN9A | |
| SCHEMBL16319328 | 0.76 | SCN9A (0.50) | SCN9AFPR2CYP2C9SCN5ASCN1A | |
| SCHEMBL15094295 | 0.75 | SCN9A (0.45) | SCN9A | |
| SCHEMBL16242041 | 0.75 | SCN9A (0.66) | SCN9AKDM4EMAPTSCN5A | |
| SCHEMBL680717 | 0.74 | MAPK14 (0.56) | SCN9AKDM4EMAPTSCN5ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |