SCHEMBL16319279

SCHEMBL16319279

COc1cc(C(=O)NS(C)(=O)=O)ccc1Oc1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 19/20 0.56
SCN5A Q14524 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16319828 0.88 SCN9A (0.70) SCN9ASCN5A
SCHEMBL680594 0.85 SCN9A (0.52) SCN9ASCN5A
SCHEMBL16242218 0.82 SCN9A (0.70) SCN9ASCN5A
SCHEMBL16319499 0.81 SCN9A (0.63) SCN9ASCN5A
SCHEMBL16319793 0.80 SCN9A (0.54) SCN9ASCN5A
SCHEMBL680427 0.79 SCN9A (0.59) SCN9ASCN5A
SCHEMBL16319487 0.78 SCN9A (0.65) SCN9ASCN5A
SCHEMBL678799 0.76 SCN9A (0.56) SCN9ASCN5A
SCHEMBL16319531 0.76 SCN9A (0.58) SCN9ASCN5A
SCHEMBL16319471 0.76 SCN9A (0.63) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593427-B1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LTD (GB) 2014-12-24 EP disclosed