Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.65 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.65 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319499 | 0.91 | SCN9A (0.63) | SCN9ASCN5AMRGPRX4PLA2G7 | |
| SCHEMBL16319828 | 0.90 | SCN9A (0.70) | SCN9ASCN5A | |
| SCHEMBL371116 | 0.89 | SCN9A (0.67) | SCN9ASCN5A | |
| SCHEMBL16319655 | 0.88 | PLA2G7 (0.62) | SCN9ASCN5APLA2G7 | |
| SCHEMBL16319531 | 0.87 | SCN9A (0.58) | SCN9ASCN5AMRGPRX4 | |
| SCHEMBL16319475 | 0.86 | SCN9A (0.62) | SCN9ASCN5A | |
| SCHEMBL680193 | 0.83 | MRGPRX4 (0.61) | SCN9ASCN5AMRGPRX4 | |
| SCHEMBL680162 | 0.83 | SCN9A (0.59) | SCN9ASCN5AMRGPRX4 | |
| SCHEMBL16319584 | 0.83 | SCN9A (0.60) | SCN9ASCN5APLA2G7 | |
| SCHEMBL369786 | 0.83 | SCN9A (0.81) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |