Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.65 |
| ▸ | KMO | O15229 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15094056 | 0.91 | SCN9A (0.55) | SCN9AKMOIGFBP3 | |
| SCHEMBL16319625 | 0.85 | SCN9A (0.50) | SCN9AHTR2ASLC6A4KCNH2 | |
| SCHEMBL15543681 | 0.84 | SCN9A (0.66) | SCN9AKMO | |
| SCHEMBL16319184 | 0.83 | KMO (0.56) | SCN9AKMOIGFBP3HSP90AA1SCN5A | |
| SCHEMBL21274769 | 0.81 | PNLIP (0.45) | SCN9A | |
| SCHEMBL16319575 | 0.79 | KMO (0.60) | SCN9AKMOHTR2ASLC6A4KCNH2 | |
| SCHEMBL5836731 | 0.79 | HTR2A (0.52) | SCN9AKMOHTR2ASLC6A4KCNH2 | |
| SCHEMBL16319598 | 0.79 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL15094313 | 0.79 | SCN9A (0.46) | SCN9ASCN5A | |
| SCHEMBL17244918 | 0.79 | SCN9A (0.51) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |