Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | KMO | O15229 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | PYGM | P11217 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.45 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310179 | 0.87 | HTR2A (0.54) | HTR2ASLC6A4KCNH2SCN9A | |
| SCHEMBL4445272 | 0.84 | PTGER4 (0.59) | KDM4EPOLBPTGER4PTGER2EPAS1 | |
| SCHEMBL5836468 | 0.83 | HTR2A (0.57) | HTR2ASLC6A4KCNH2PTGER4SCN9A | |
| SCHEMBL4739689 | 0.83 | KMO (0.56) | HTR2ASLC6A4KCNH2KMOKDM4E | |
| SCHEMBL30775030 | 0.83 | KMO (0.56) | HTR2ASLC6A4KCNH2KMOKDM4E | |
| SCHEMBL14541622 | 0.82 | HTR2A (0.58) | HTR2ASLC6A4KCNH2SCN9A | |
| SCHEMBL5837318 | 0.81 | HTR2A (0.52) | HTR2ASLC6A4KCNH2SCN9A | |
| SCHEMBL4112011 | 0.80 | SCN8A (0.55) | HTR2ASLC6A4KDM4EPOLBPTGER4 | |
| SCHEMBL2330578 | 0.79 | ALDH1A1 (0.51) | KCNH2POLBPTGER4EPAS1KEAP1 | |
| SCHEMBL16319305 | 0.79 | SCN9A (0.65) | HTR2ASLC6A4KCNH2KMOSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084165-B2 | Monoamine reuptake inhibitors for treatment of CNS disorders | PFIZER INC (US) | 2006-08-01 | — | — | US | disclosed |
| US-20040048856-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | PFIZER INC | 2004-03-11 | — | — | US | disclosed |
| US-6677378-B2 | AS SEROTONIN, NOREPINEPHRINE AND DOPAMINE REUPTAKE INHIBITORS, FOR THERAPY OF CENTRAL NERVOUS SYSTEM AND OTHER DISORDERS | PFIZER INC. | 2004-01-13 | — | — | US | disclosed |
| US-20020143003-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | PFIZER INC. | 2002-10-03 | — | — | US | disclosed |
| EP-1154984-A1 | INHIBITORS FOR UPTAKE OF SEROTONINE, DOPAMINE OR NOREPINEPHRINE | Pfizer Products Inc. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050380-A1 | MONOAMINE REUPTAKE INHIBITORS FOR TREATMENT OF CNS DISORDERS | PFIZER PRODUCTS INC. (US) | 2000-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143003-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | SLC6A2, SLC6A4, SLC6A3 | HTR2A 24/4885SLC6A4 2/4885KCNH2 1224/4885 |
| US-20040048856-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | SLC6A2, SLC6A3, SLC18A2 | HTR2A 14/4885SLC6A4 4/4885KCNH2 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.