Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 12/20 | 0.61 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319655 | 0.88 | PLA2G7 (0.62) | SCN9APLA2G7SCN5A | |
| SCHEMBL16319475 | 0.86 | SCN9A (0.62) | SCN9ASCN5AHTR2ASLC6A4KCNH2 | |
| SCHEMBL679917 | 0.85 | SCN9A (0.50) | SCN9APLA2G7SCN5ASLC22A12 | |
| SCHEMBL680832 | 0.84 | PLA2G7 (0.55) | SCN9APLA2G7SCN5A | |
| SCHEMBL16319613 | 0.84 | SCN9A (0.60) | SCN9AHTR2ASLC6A4KCNH2 | |
| SCHEMBL680332 | 0.84 | SCN9A (0.53) | SCN9ASCN5APGR | |
| SCHEMBL680156 | 0.83 | SCN9A (0.52) | SCN9ASCN5ASLC22A12 | |
| SCHEMBL16319310 | 0.83 | SCN9A (0.71) | SCN9ASCN5A | |
| SCHEMBL680427 | 0.83 | SCN9A (0.59) | SCN9ASCN5ABCL2L1MCL1 | |
| SCHEMBL680375 | 0.82 | SCN9A (0.50) | SCN9APLA2G7SCN5ABCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |