Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.55 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371316 | 0.81 | SCN9A (0.50) | KDRSCN9A | |
| SCHEMBL16319859 | 0.79 | MMP1 (0.56) | MMP1FLT1FLT4KDRBCL2L1 | |
| SCHEMBL16320154 | 0.77 | MMP1 (0.57) | MMP1FLT1FLT4KDRBCL2L1 | |
| SCHEMBL17113311 | 0.75 | OGG1 (0.47) | ALDH1A1SCN9A | |
| SCHEMBL29865510 | 0.75 | MEN1 (0.49) | KMT2AMEN1LMNAMAPTSCN9A | |
| SCHEMBL3808268 | 0.75 | HDAC3 (0.50) | FLT1FLT4KDRKMT2AMEN1 | |
| SCHEMBL16361274 | 0.75 | SCN9A (0.49) | NPC1RAB9AALDH1A1LMNASCN2B | |
| SCHEMBL29625497 | 0.72 | NPC1 (0.54) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL29865596 | 0.71 | FLT1 (0.56) | MMP1FLT1FLT4KDRMMP2 | |
| SCHEMBL809338 | 0.70 | KMT2A (0.69) | KMT2AMEN1NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |