SCHEMBL16319352

SCHEMBL16319352

COc1ccc(F)c(-c2ccc(COc3ncnc(C=CC(=O)O)c3C)nc2CC(C)(C)C)c1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 12/20 0.52
FFAR4 Q5NUL3 1/20 0.34
GRK6 P43250 1/20 0.34
LTB4R Q15722 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16319351 1.00 FFAR1 (0.52) FFAR1FFAR4GRK6LTB4R
SCHEMBL16319091 0.93 FFAR1 (0.52) FFAR1FFAR4GRK6LTB4R
SCHEMBL16319090 0.93 FFAR1 (0.52) FFAR1FFAR4GRK6LTB4R
SCHEMBL16319344 0.92 FFAR1 (0.52) FFAR1FFAR4GRK6LTB4R
SCHEMBL16319345 0.92 FFAR1 (0.52) FFAR1FFAR4GRK6LTB4R
SCHEMBL16319151 0.84 FFAR1 (0.55) FFAR1FFAR4GRK6
SCHEMBL16319205 0.83 FFAR1 (0.51) FFAR1GRK6
SCHEMBL16319270 0.82 FFAR1 (0.52) FFAR1GRK6
SCHEMBL16319271 0.82 FFAR1 (0.52) FFAR1GRK6
SCHEMBL16318839 0.80 FFAR1 (0.49) FFAR1GRK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9181186-B2 Aromatic ring compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-11-10 US disclosed
US-20150045378-A1 AROMATIC RING COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-02-12 US disclosed
EP-2816032-A1 AROMATIC RING COMPOUND Takeda Pharmaceutical Company Limited (JP) 2014-12-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150045378-A1 AROMATIC RING COMPOUND GPR119, GPR27, GPR4 FFAR1 31/4885FFAR4 26/4885GRK6 394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.