Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274851 | 0.74 | MAPK8 (0.60) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL31061416 | 0.74 | MAPK8 (0.60) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL9501452 | 0.72 | MAPK8 (0.58) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL16319417 | 0.71 | KDM4E (0.46) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL20336230 | 0.70 | KDM4E (0.73) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL11523761 | 0.70 | KDM4E (0.73) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL4495740 | 0.70 | KDM4E (0.73) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL29449726 | 0.70 | KDM4E (0.73) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL11086979 | 0.70 | P2RX7 (0.55) | MAPTKDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL10787690 | 0.70 | MAPK8 (0.52) | MAPTKDM4EGAAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-B1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-24 | — | — | EP | disclosed |