Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.59 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319332 | 0.81 | SCN9A (0.61) | PLA2G7HTR2ASLC6A4KCNH2SLC22A12 | |
| SCHEMBL6044963 | 0.81 | PARP10 (0.57) | PLA2G7ALDH1A1HPGDLPAR1LPAR5 | |
| SCHEMBL4151526 | 0.81 | HPGD (0.51) | PLA2G7ALDH1A1HPGDSLC22A12AR | |
| SCHEMBL16319575 | 0.79 | KMO (0.60) | KMOMRGPRX4TSHRHTR2ASLC6A4 | |
| SCHEMBL364842 | 0.79 | KMO (0.60) | KMOMRGPRX4TSHRALDH1A1HTR2A | |
| SCHEMBL1923911 | 0.77 | TSHR (0.59) | KMOMRGPRX4TSHRALDH1A1HPGD | |
| SCHEMBL15096334 | 0.77 | AR (0.54) | MRGPRX4ALDH1A1HPGDARLPAR1 | |
| SCHEMBL14081445 | 0.77 | AR (0.57) | PLA2G7HTR2ASLC6A4KCNH2SLC22A12 | |
| SCHEMBL5837296 | 0.77 | SLC22A12 (0.57) | PLA2G7ALDH1A1HPGDHTR2ASLC6A4 | |
| SCHEMBL28288101 | 0.77 | HTR2A (0.55) | PLA2G7TSHRALDH1A1HPGDHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |