Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16320397 | 0.79 | FAAH (0.44) | HDAC6CA2FAAHTRPA1EPHX2 | |
| SCHEMBL1238942 | 0.76 | NPC1 (0.50) | OPRM1PARP15PARP10OPRD1CD38 | |
| SCHEMBL16319711 | 0.76 | NPC1 (0.41) | CD38OPRK1KMT2AMEN1NPC1 | |
| SCHEMBL5547776 | 0.73 | RXFP1 (0.45) | OPRM1OPRK1HDAC6HDAC3HDAC4 | |
| SCHEMBL16319993 | 0.72 | TSHR (0.43) | KMT2AMEN1NAMPT | |
| SCHEMBL2792642 | 0.70 | CD38 (0.41) | PARP15PARP10CD38KMT2AMEN1 | |
| SCHEMBL16319436 | 0.69 | MAPK8 (0.42) | HDAC6FAAHTRPA1EPHX2FAAH2 | |
| SCHEMBL23169493 | 0.69 | JAK2 (0.47) | PARP15PARP10CD38HDAC6HDAC3 | |
| SCHEMBL4961543 | 0.68 | FAAH (0.59) | OPRM1OPRK1HDAC6KMT2AMEN1 | |
| SCHEMBL3090215 | 0.67 | HDAC6 (0.71) | OPRM1PARP15PARP10OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-B1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-24 | — | — | EP | disclosed |