Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | FAAH2 | Q6GMR7 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319436 | 0.87 | MAPK8 (0.42) | FAAHTRPA1EPHX2FAAH2MGLL | |
| SCHEMBL16320026 | 0.87 | HCAR3 (0.48) | HDAC8 | |
| SCHEMBL8170956 | 0.85 | F2 (0.40) | HDAC8ALOX15 | |
| SCHEMBL16320332 | 0.84 | RAB9A (0.52) | — | |
| SCHEMBL16319748 | 0.82 | FYN (0.43) | HDAC8ALOX15 | |
| SCHEMBL16319555 | 0.81 | HPGD (0.45) | EPHX2 | |
| SCHEMBL16319407 | 0.79 | OPRM1 (0.42) | FAAHTRPA1EPHX2FAAH2MGLL | |
| SCHEMBL16319440 | 0.79 | SMN1; SMN2 (0.48) | EPHX2HDAC6HDAC8ALOX15 | |
| SCHEMBL16319842 | 0.77 | BMPR1B (0.45) | — | |
| SCHEMBL16319839 | 0.76 | KDM4E (0.42) | ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-B1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-24 | — | — | EP | disclosed |