Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.51 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | PPOX | P50336 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365318 | 0.91 | SCN9A (0.50) | SCN9APLA2G7MEN1TTRPPOX | |
| SCHEMBL16319358 | 0.84 | SCN9A (0.48) | SCN9APLA2G7PPARGPPARABRAF | |
| SCHEMBL364276 | 0.83 | SCN9A (0.54) | SCN9APLA2G7NOTUMPPARGPPARA | |
| SCHEMBL16319316 | 0.82 | PPARG (0.49) | SCN9APLA2G7NOTUMPPARGPPARA | |
| SCHEMBL364840 | 0.82 | SCN9A (0.69) | SCN9APLA2G7MEN1TTRPPOX | |
| SCHEMBL16319584 | 0.82 | SCN9A (0.60) | SCN9APLA2G7 | |
| SCHEMBL16319404 | 0.81 | SCN9A (0.53) | SCN9APLA2G7NOTUMPPARGPPARA | |
| SCHEMBL16319690 | 0.80 | PLA2G7 (0.53) | SCN9APLA2G7PPARGPPARAMRGPRX4 | |
| SCHEMBL16319785 | 0.79 | PLA2G7 (0.55) | SCN9APLA2G7MEN1TTRPPOX | |
| SCHEMBL16319516 | 0.79 | SCN9A (0.48) | SCN9APLA2G7MEN1KMT2ABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |