Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319785 | 0.90 | PLA2G7 (0.55) | PLA2G7SCN9APPARGPPARAMRGPRX4 | |
| SCHEMBL16319599 | 0.86 | SCN9A (0.52) | PLA2G7SCN9ALMNARAB9ABRAF | |
| SCHEMBL16319575 | 0.85 | KMO (0.60) | SCN9ALMNAMAPK1HTTRAB9A | |
| SCHEMBL365436 | 0.84 | SCN9A (0.47) | PLA2G7SCN9APPARGPPARAMRGPRX4 | |
| SCHEMBL365495 | 0.84 | PLA2G7 (0.53) | PLA2G7BRAFKDRPPARGPPARA | |
| SCHEMBL16319499 | 0.82 | SCN9A (0.63) | PLA2G7SCN9AMRGPRX4 | |
| SCHEMBL16319437 | 0.82 | KMO (0.56) | PLA2G7HTTIGFBP3MRGPRX4KMO | |
| SCHEMBL21656739 | 0.80 | IGFBP3 (0.59) | LMNAMAPK1HTTRAB9AIGFBP3 | |
| SCHEMBL16319441 | 0.80 | SCN9A (0.51) | PLA2G7SCN9ABRAFKDRPPARG | |
| SCHEMBL364840 | 0.80 | SCN9A (0.69) | PLA2G7SCN9APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |