Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319521 | 0.85 | SCN9A (0.49) | SCN9APPARGPPARAPLA2G7BRAF | |
| SCHEMBL16319606 | 0.84 | SCN9A (0.48) | SCN9APPARGPPARAPLA2G7BRAF | |
| SCHEMBL16319308 | 0.82 | SCN9A (0.59) | SCN9APLA2G7 | |
| SCHEMBL16319441 | 0.81 | SCN9A (0.51) | SCN9APPARGPPARAPLA2G7EGLN1 | |
| SCHEMBL364840 | 0.81 | SCN9A (0.69) | SCN9APPARGPPARAPLA2G7NOTUM | |
| SCHEMBL16319690 | 0.79 | PLA2G7 (0.53) | SCN9APPARGPPARAPLA2G7EGLN1 | |
| SCHEMBL365318 | 0.78 | SCN9A (0.50) | SCN9APPARGPPARAPLA2G7EGLN1 | |
| SCHEMBL364276 | 0.76 | SCN9A (0.54) | SCN9APPARGPPARAPLA2G7NOTUM | |
| SCHEMBL16319785 | 0.75 | PLA2G7 (0.55) | SCN9APPARGPPARAPLA2G7EGLN1 | |
| SCHEMBL365436 | 0.75 | SCN9A (0.47) | SCN9APPARGPPARAPLA2G7CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |