Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.60 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319499 | 0.87 | SCN9A (0.63) | SCN9ASCN5APLA2G7 | |
| SCHEMBL371116 | 0.86 | SCN9A (0.67) | SCN9ASCN5ARAF1KDR | |
| SCHEMBL16319523 | 0.83 | SCN9A (0.56) | SCN9ASCN5ARAF1KDR | |
| SCHEMBL680222 | 0.83 | SCN9A (0.63) | SCN9ASCN5A | |
| SCHEMBL16319487 | 0.82 | SCN9A (0.65) | SCN9ASCN5APLA2G7 | |
| SCHEMBL365436 | 0.81 | SCN9A (0.47) | SCN9APLA2G7RAF1 | |
| SCHEMBL370953 | 0.81 | SCN9A (0.55) | SCN9ASCN5ALMNAGAAMAPT | |
| SCHEMBL16319642 | 0.81 | SCN9A (0.57) | SCN9ASCN5ARAF1KDR | |
| SCHEMBL16319431 | 0.81 | SCN9A (0.68) | SCN9ASCN5A | |
| SCHEMBL16319537 | 0.81 | SCN9A (0.78) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |