Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.49 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.49 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11696831 | 0.83 | KMT2A (0.63) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL8902333 | 0.81 | PARP10 (0.50) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL1989785 | 0.78 | PARP10 (0.79) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL11355202 | 0.78 | SLC6A2 (0.58) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL8901334 | 0.77 | MAPT (0.48) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL29375569 | 0.74 | MAPK1 (0.58) | PARP10KMT2AALDH1A1PARP4PARP2 | |
| SCHEMBL27486876 | 0.72 | PARP10 (0.59) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL5830169 | 0.72 | TAAR5 (0.46) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL2954394 | 0.71 | PARP1 (0.49) | PARP10KMT2APARP15PARP14ALDH1A1 | |
| SCHEMBL16319237 | 0.71 | SLC6A4 (0.66) | PARP10KMT2APARP15PARP14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |