SCHEMBL16319606

SCHEMBL16319606

O=C(O)c1c(F)cc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 4/20 0.48
PPARG P37231 2/20 0.47
PPARA Q07869 1/20 0.47
KDR P35968 6/20 0.43
BRAF P15056 3/20 0.43
RAF1 P04049 3/20 0.43
FLT1 P17948 2/20 0.43
RIPK2 O43353 1/20 0.43
ABCB11 O95342 1/20 0.43
ABL1 P00519 1/20 0.43
NR3C1 P04150 1/20 0.43
RET P07949 1/20 0.43
HTR1A P08908 1/20 0.43
PDGFRB P09619 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
KIT P10721 1/20 0.43
CHRM1 P11229 1/20 0.43
BCR P11274 1/20 0.43
FGFR1 P11362 1/20 0.43
RARG P13631 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL364276 0.86 SCN9A (0.54) SCN9APPARGPPARAKDRBRAF
SCHEMBL16319404 0.84 SCN9A (0.53) SCN9APPARGPPARAKDRBRAF
SCHEMBL16319579 0.83 SCN9A (0.45) SCN9APPARGPPARAKDRBRAF
SCHEMBL365495 0.81 PLA2G7 (0.53) PPARGPPARAKDRBRAFRAF1
SCHEMBL16319523 0.80 SCN9A (0.56) SCN9AKDRBRAFRAF1FLT1
SCHEMBL16319316 0.80 PPARG (0.49) SCN9APPARGPPARAKDRBRAF
SCHEMBL365436 0.80 SCN9A (0.47) SCN9APPARGPPARARAF1EPHX2
SCHEMBL16319690 0.77 PLA2G7 (0.53) SCN9APPARGPPARAKDRBRAF
SCHEMBL364840 0.77 SCN9A (0.69) SCN9APPARGPPARAPLA2G7
SCHEMBL5668761 0.76 PPARG (0.52) PPARGPPARAKDRRAF1CHEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593427-B1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LTD (GB) 2014-12-24 EP disclosed