Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679836 | 0.88 | SCN9A (0.51) | SCN9ASCN5ASLC22A12 | |
| SCHEMBL16319471 | 0.83 | SCN9A (0.63) | SCN9ASCN5ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL680156 | 0.82 | SCN9A (0.52) | SCN9ASCN5ASLC22A12 | |
| SCHEMBL679917 | 0.82 | SCN9A (0.50) | SCN9ASCN5ASLC22A12 | |
| SCHEMBL678799 | 0.82 | SCN9A (0.56) | SCN9ASCN5ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16319332 | 0.79 | SCN9A (0.61) | SCN9ASCN5ASLC6A4SLC22A12 | |
| SCHEMBL680209 | 0.79 | SCN9A (0.48) | SCN9ASCN5A | |
| SCHEMBL16319802 | 0.79 | SCN9A (0.63) | SCN9A | |
| SCHEMBL681098 | 0.79 | EZH2 (0.49) | SCN9ASCN5ASLC22A12 | |
| SCHEMBL367120 | 0.78 | HDAC8 (0.55) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |