Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13723295 | 0.81 | PARP10 (0.41) | MAOAMAOBPARP10PARP15SLC6A4 | |
| SCHEMBL15474826 | 0.79 | MAOA (0.48) | MAOAMAOBPARP10PARP15 | |
| SCHEMBL15474787 | 0.78 | PARP10 (0.40) | MAOAMAOBPARP10PARP15SLC6A4 | |
| SCHEMBL2376907 | 0.78 | SLC6A4 (0.49) | PTGER1MAOAMAOBPARP10PARP15 | |
| SCHEMBL13722740 | 0.76 | PARP10 (0.40) | PARP10PARP15 | |
| SCHEMBL2376749 | 0.75 | SLC6A2 (0.42) | MAOAMAOBPTGDR2PARP10PARP15 | |
| SCHEMBL160634 | 0.75 | MAPT (0.36) | MAOBPTGS2 | |
| SCHEMBL21430664 | 0.74 | KMT2A (0.52) | PDK2PARP10 | |
| SCHEMBL6226618 | 0.73 | L3MBTL1 (0.41) | MAOB | |
| SCHEMBL5547776 | 0.72 | RXFP1 (0.45) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-B1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-24 | — | — | EP | disclosed |